OverviewSymptomsCausesRisk FactorsComplicationsPreventionWhooping cough (pertussis) is a highly contagious respiratory tract infection. In many people, it's marked by a severe hacking cough followed
by a high-pitched intake of breath that sounds like "whoop."Before the vaccine was developed, whooping cough was considered a childhood disease. Now whooping cough primarily affects children too young to have
completed the full course of vaccinations and teenagers and adults whose immunity has faded.Deaths associated with whooping cough are rare but mosSee more on mayoclinic.org TrendsCase DefinitionPertussis Surveillance ReportsReferencesPertussis is nationally-notifiable and clinicians should notify the appropriate health department of all patients with suspected pertussis. Similarly, diagnostic laboratories should notify health departments of all positive pertussis laboratory results. State health departments then report confirmed and probable pertussis cases to CDC through the National Notifiable Diseases Surveillance System (NNDSS). Although many pertussis cases are not diagnosed and therefore not reported, the surveillanSee more on cdc.gov Virulence factor of Bordetella pertussis that is an adenylate cyclase toxin which increases
cAMP levels leading to edema and inhibits chemokine receptors to impair neutrophil chemotaxis producing lymphocytosis; Also activates Pancreas islet cells leading to … Bordetella
PertussisPathogenesisReferenceB. pertussis is a fastidious, gram-negative bacterium requiring special media for isolation. B. pertussis produces multiple antigenic and biologically active products including: 1. Pertussis toxin 2. Filamentous hemagglutinin (FHA) 3. Agglutinogens 4. Adenylate cyclase 5. Pertactin 6. Tracheal cytotoxinThese products are responsible for the clinical features of pertussis and an immune response to one or more produces immunity following infection. Some observational studies suggest that pertusSee more on cdc.gov Bordetella pertussis (B. Pertussis) is a small, coccobacillus.Coccobacillus are rod-shaped bacteria. Cocco comes from "cocci" meaning spherical shaped and bacillus comes from "bacilli" meaning elongated. Whooping cough commonly affects
infants and young children. Immunization with the pertussis vaccine prevents the infection. Physicians commonly give the pertussis vaccine in combination with the vaccines for diphtheria and tetanus. (Pertussis is the "P" in the DTaP combination inoculation routinely given to children, and the "p" in the Tdap Disease
CycleSymptomsStatisticsVaccinationTreatmentRelated Diseases/SequelaeSource: http://www.cmaj.ca/content/172/4/509/F1.expansion.htmlAfter initial airborn tramsmission through coughing, the bacteria attaches itself to the cilia in the airways of the upper respiratory system of the human host . Bordetella pertussis contains Pertussis toxin (PT), “Filamentous hemagglutinin (FHA), fimbrae, and pertactin (PRN)” which help the bacteria to cling to the tissue found in such
areas as the nose and throat . The bacteria also uses a compound called tracheal cytotoxinSee more on wiki.ggc.usg.edu Author: Jennifer J. Brown Class: BetaproteobacteriaGenus: BordetellaFamily: AlcaligenaceaePhylum: Proteobacteria Answers from doctors on pertussis life cycle. First: Life cycles in biology refer to organisms that have different appearances and abilities in different generations. Leprosy bacteria grow best at cooler temperatures inside cells, and you will probably find them interesting; I have the idea that they are a modified tubercle bacillus that has lost much of its genome.